Mary, I hand quilted my DGD's wedding quilt and it was a king. I started it on my quilt frame but it was larger than the frame so couldn't do much there. Then, I used a hoop in the middle section because I wanted to avoid any tucks. But I ended up putting the frame aside. I have a large oval hoop and it just seemed to get in the way of my reaching to the middle.
Like everything else, you have to experiment with what works for you. I'll quilt the LBB by hand when I ever get to that point. Let's hope I live that long.
And, just so you all know, I've seen Mary's LBB blocks and they are beautiful.